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Dopamine D1 Receptor in Cancer
Paweł Sobczuk1,2, Michał Łomiak1, Agnieszka Cudnoch-Jędrzejewska1
1Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland.
Cancers
|November 5, 2020
Summary
The dopamine D1 receptor influences cancer development by regulating tumor growth and spread. Activating this receptor shows promise for suppressing tumors and preventing metastasis, potentially enhancing cancer treatments.
Area of Science:
- Neuroscience
- Oncology
- Pharmacology
Background:
- Dopamine, a catecholamine, functions as a hormone and neurotransmitter.
- Dopamine receptors, particularly D1-like and D2-like families, modulate CNS and peripheral functions.
- The dopamine D1 receptor (D1R) is increasingly implicated in human neoplasm development.
Purpose of the Study:
- To comprehensively review the molecular roles and signaling pathways of the dopamine D1 receptor in human neoplasm development.
- To explore therapeutic targeting of the dopamine D1 receptor as an adjunct anti-cancer strategy.
Main Methods:
- Literature review of recent studies on dopamine D1 receptor in cancer.
- Analysis of D1R's role in regulating tumor cell proliferation, apoptosis, autophagy, migration, and invasiveness.
- Examination of D1R's impact on cancer stem cells and tumor microvasculature.
Main Results:
- Dopamine D1 receptor activation suppresses tumor growth and metastasis.
- D1R activation promotes tumor microvasculature maturation.
- Synergistic anti-cancer effects observed when D1R agonists are combined with tyrosine kinase inhibitors or temozolomide.
Conclusions:
- The dopamine D1 receptor plays a heterogeneous role in human neoplasm development.
- Targeting the dopamine D1 receptor presents a potential adjunct anti-cancer therapeutic strategy.
- Further research is needed to elucidate D1R's precise mechanisms and optimize its therapeutic application.
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