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Updated: Dec 2, 2025
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
Published on: April 28, 2015
HEMATOLOGICAL CHANGES AFTER INTRODUCTION OF DIFFERENT SIZES LEAD NANOPARTICLES (IN EXPERIMENT)
Inna V Gubar1, Olena L Apykhtina2, Oleksandr P Yavorovsky3
1BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE; STATE INSTITUTION KUNDIIEV INSTITUTE OF OCCUPATIONAL HEALTH OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE; EDUCATIONAL AND SCIENTIFIC CENTER "INSTITUTE OF BIOLOGY AND MEDICINE" OF TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE.
Objective:
The aim: Was to compare the changes in hematological parameters of blood in the conditions of prolonged exposure of lead sulfide nanoparticles (NP) of different sizes and of lead nitrate.
Patients And Methods:
Materials and methods: The study was conducted on mature male Wistar rats 160-180 g, intraperitoneally injected with Pb(NO3)2 and NP PbS of 26-34 nm and 50-80 nm in 0,94 mg/kg/day dose adjusted to lead. Toxic effects were evaluated after 1,5 months, 3 months and 1 month after exposure. The studies were performed on hematologic analyzer.
Results:
Results: Changes in peripheral blood were characterized by decrease in the hemoglobin level in the blood. An increase in the total number of leucocytes was observed, which is statistically significant by the increase of number of lymphocytes and the absolute number of monocytes. Changes in the platelet number were characterized by an increase in the average volume of platelets and a decrease in the platelet heterogeneity index.
Conclusion:
Conclusions: The most pronounced changes hemoglobin level in the blood and concentration of hemoglobin in the erythrocyte were observed in the effects of PbS NP (50-80 nm), but leucocytes indicators - of PbS NP (26-34 nm) and Pb(NO3)2.
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