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Intraocular reticulum cell sarcoma: diagnosis by choroidal biopsy
M H Kirmani1, E L Thomas, N A Rao
1Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles 90033.
The British Journal of Ophthalmology
|October 1, 1987
Summary
Transscleral biopsy diagnosed reticulum cell sarcoma in a patient with uveitis when other methods failed. Early detection via this biopsy preserved the patient's eye and vision.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Reticulum cell sarcoma (RCS) can manifest in the eye, presenting diagnostic challenges.
- Uveitis and retinal pigment epithelial detachments are potential signs of intraocular malignancy.
Observation:
- A patient with suspected intraocular RCS underwent extensive examinations, including pars plana vitrectomy, which failed to detect malignancy.
- Subretinal lesions were biopsied via a transscleral approach.
Findings:
- Transscleral biopsy confirmed the histopathological diagnosis of reticulum cell sarcoma.
- The patient received systemic chemotherapy and ocular/orbital radiation therapy.
Implications:
- Transscleral biopsy is a valuable diagnostic tool for intraocular reticulum cell sarcoma, especially when vitreous biopsies are negative.
- Early diagnosis and treatment led to eye and vision preservation and potentially improved prognosis.