Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow
Canchen Wu1, Danqi Wang, Moupan Cen
1School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, China. ywang85@ntu.edu.cn ttchen1980@126.com yaoyong1986@ntu.edu.cn.
Abstract:
An intelligent nitric oxide gas-releasing nanoplatform based on CuS-nanoplates has been designed to overcome the heat endurance of tumor cells by the inhibition of HSP90 expression with the released NO gas in mitochondria and thereby realize enhanced PTT under mild temperature conditions.
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