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Communication-related assessments in an Angelman syndrome mouse model
Peter A Perrino1, Stormy J Chamberlain2, Inge-Marie Eigsti3
1Department of Psychological Science/Behavioral Neuroscience, University of Connecticut, Storrs, CT, USA.
Brain and Behavior
|November 5, 2020
Summary
Angelman syndrome (AS) mouse models show motor deficits impacting communication. Motor impairments strongly correlate with reduced ultrasonic vocalizations, highlighting a key factor in AS communicative disabilities.
Area of Science:
- Neuroscience
- Genetics
- Developmental Biology
Background:
- Angelman syndrome (AS) is a neurodevelopmental disorder caused by UBE3A gene dysfunction.
- AS is characterized by motor deficits, seizures, and severe speech impairment.
- Previous AS mouse models have not fully explored communication deficits.
Purpose of the Study:
- To investigate communication deficits in a mouse model of Angelman syndrome.
- To assess auditory processing and social communication in AS mice.
- To correlate motor and acoustic behaviors with vocalization output.
Main Methods:
- Utilized behavioral tasks assessing rapid auditory processing and social communication.
- Directly assessed expressive vocalizations (ultrasonic) in AS mice.
- Correlated vocalizations with motor, social, and acoustic perception measures.
Main Results:
- AS mice exhibited characteristic social and motor deficits.
- Marginal enhancements in rapid auditory processing were observed.
- AS mice produced fewer and shorter ultrasonic vocalizations compared to controls.
- Motor deficits significantly correlated with reduced vocalization output.
Conclusions:
- AS mouse model phenotypes parallel human Angelman syndrome symptoms.
- Motor impairments are a significant contributor to communication deficits in AS.
- This model provides a tool to study AS-related communication impairments.
