Related Experiment Video

Updated: Dec 2, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

15.0K

Phosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis

Yi Patrick Lu1, Shujun Fan2, Zhen Liang1

  • 1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

The World Journal of Men'S Health
|November 5, 2020
PubMed
Abstract

Insights

Phosphodiesterase type 5 inhibitors (PDE5Is) use shows a slight association with an increased risk of skin cancers, including malignant melanoma. Further research is needed to control for confounding factors like sun exposure.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Phosphodiesterase type 5 inhibitors (PDE5Is) are widely used for erectile dysfunction.
  • The potential link between PDE5Is and skin cancer risk requires thorough investigation.
  • Gene expression, specifically PDE5A, may influence malignant melanoma prognosis.

Purpose of the Study:

  • To systematically review and meta-analyze the association between PDE5Is use and skin cancer risk.
  • To investigate the correlation between PDE5A gene down-expression and malignant melanoma patient outcomes.

Main Methods:

  • Searched major databases (PubMed, EMBASE, etc.) for relevant studies.
  • Calculated odds ratios (ORs) and 95% confidence intervals (CIs) for skin cancer risk.
  • Conducted cumulative meta-analysis and trial sequential analysis (TSA).

Main Results:

  • PDE5Is use was linked to a slightly increased risk of malignant melanoma (OR: 1.13), basal cell carcinoma (OR: 1.16), and squamous cell carcinoma (OR: 1.07).
  • Overall, PDE5Is use showed a significant association with a slightly higher risk of skin cancers (OR: 1.13).
  • TSA confirmed sufficient sample size for a conclusive finding.

Conclusions:

  • PDE5Is use may be associated with a modest increase in skin cancer risk.
  • Balancing therapeutic benefits against potential safety concerns is crucial.
  • Further studies controlling for sun exposure and lifestyle are necessary to confirm these findings.
Keywords:
Erectile dysfunctionMelanomaMeta-analysisPhosphodiesterase type 5 inhibitorsSkin neoplasms

More Related Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.3K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.6K

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
356
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.4K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
95
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
281
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.3K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.3K