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Related Experiment Videos

Transdermal drug delivery: problems and possibilities.

V M Knepp1, J Hadgraft, R H Guy

  • 1Department of Pharmaceutical Chemistry, University of California at San Francisco.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

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Transdermal drug delivery offers systemic benefits but faces limitations in drug properties. Further research is needed to understand skin absorption and optimize this delivery route.

Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Dermatology

Background:

  • Transdermal drug delivery is gaining interest for systemic therapeutic effects.
  • Significant limitations exist regarding the physiochemical and pharmacological properties of drugs for transdermal use.
  • Understanding the skin's role in drug absorption is crucial.

Purpose of the Study:

  • To review the current status and achievements in transdermal drug delivery.
  • To address the benefits, drawbacks, and unresolved issues of transdermal administration.
  • To identify knowledge gaps in percutaneous absorption and discuss methods to address them.

Main Methods:

  • Literature review of transdermal drug delivery accomplishments.
  • Analysis of benefits, disadvantages, and challenges in transdermal drug administration.

Related Experiment Videos

  • Identification of deficiencies in understanding human percutaneous absorption.
  • Discussion of experimental and modeling techniques for assessing therapeutic candidates.

    • Main Results:

    • Transdermal drug delivery presents advantages but is constrained by drug properties.
    • Key challenges include limitations in drug physiochemistry and pharmacology.
    • Deficiencies in understanding human percutaneous absorption processes were identified.

    Conclusions:

    • Transdermal drug delivery holds promise but requires overcoming significant limitations.
    • Further research into percutaneous absorption mechanisms is essential.
    • Experimental and modeling approaches are vital for evaluating future transdermal therapeutic candidates.