Urinary Biomarkers for Neurodegenerative Diseases
Wongi Seol1, Hyejung Kim1, Ilhong Son1,2
1InAm Neuroscience Research Center, Gunpo 15865, Korea.
Experimental Neurobiology
|November 6, 2020
Summary
Diagnosing neurodegenerative diseases like Alzheimer's and Parkinson's early is difficult. Recent research shows urine biomarkers, identified through metabolomic and proteomic studies, offer a promising, non-invasive diagnostic tool.
Area of Science:
- Neuroscience
- Biochemistry
- Medical Diagnostics
Background:
- Global incidence of neurodegenerative diseases (NDDs) like Alzheimer's (AD) and Parkinson's (PD) is rising.
- Early diagnosis of NDDs is challenging, highlighting the need for reliable biomarkers.
- Urine, an accessible biofluid, is increasingly explored for non-central nervous system (CNS) disease diagnostics.
Purpose of the Study:
- To review recent studies investigating urine as a source for NDD biomarkers.
- To explore the potential of metabolomic and proteomic approaches in identifying urinary NDD markers.
- To discuss the challenges and advancements in using urine for NDD diagnosis and therapeutic monitoring.
Main Methods:
- Review of existing literature on NDD biomarkers in urine.
- Analysis of metabolomic and proteomic studies identifying potential urinary markers for NDDs.
- Comparison of urine as a biofluid with cerebrospinal fluid (CSF) and plasma for NDD biomarker discovery.
Main Results:
- Recent studies suggest urine can serve as a source for NDD biomarkers.
- Metabolomic and proteomic analyses are key to identifying specific urinary markers.
- Urine offers a non-invasive alternative to CSF and plasma for NDD diagnostics.
Conclusions:
- Urine holds significant potential as a non-invasive biofluid for NDD biomarker discovery.
- Further research utilizing advanced analytical techniques is crucial for validating urinary NDD biomarkers.
- Urinary biomarkers could revolutionize early detection and monitoring of neurodegenerative diseases.
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