Related Experiment Video
Updated: Dec 2, 2025
07:41
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
Published on: February 3, 2016
14.5K
Paediatric COVID-19 and the GUT.
Rohit Gupta1, Saman Beg2, Alok Jain1
1Department of Gastroenterology, AIIMS, Rishikesh, Uttarakhand, India.
Indian Journal of Medical Microbiology
|November 6, 2020
Summary
Children with COVID-19 can experience gastrointestinal symptoms, suggesting potential fecal-oral transmission. The gastrointestinal tract may shed the virus even after respiratory symptoms resolve.
Area of Science:
- Pediatrics
- Infectious Diseases
- Gastroenterology
Background:
- Novel coronavirus infection (COVID-19) in children often presents with fever and respiratory symptoms.
- Gastrointestinal (GI) symptoms like vomiting and diarrhea are also reported in pediatric COVID-19 cases.
- The GI tract's role in COVID-19 shedding and transmission is an emerging area of concern.
Purpose of the Study:
- To explore the significance of gastrointestinal symptoms in pediatric COVID-19.
- To investigate the potential for fecal-oral transmission of SARS-CoV-2 in children.
- To understand the implications of COVID-19 for children with chronic digestive conditions.
Main Methods:
- Analysis of viral RNA detection in fecal samples compared to nasopharyngeal swabs.
- Review of the expression of key SARS-CoV-2 entry proteins (ACE2, TMPRSS2) in the GI tract.
- Discussion of clinical implications for pediatric patients.
Main Results:
- Continuous detection of viral RNA in feces suggests the GI tract as a shedding source.
- Viral shedding from the GI tract may persist even after negative respiratory tests.
- Presence of SARS-CoV-2 entry receptors in the GI tract explains observed digestive symptoms.
Conclusions:
- The gastrointestinal tract plays a role in SARS-CoV-2 shedding in children.
- Fecal-oral transmission is a potential route for COVID-19 spread in pediatric populations.
- COVID-19 management requires consideration of GI symptoms and risks for children with inflammatory bowel disease.
More Related Videos
Related Concept Videos
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
130
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
130
01:26Pharmacokinetics: Drug–Food and Drug–Viral Interactions
89
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
89
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
99
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
99
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
120
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
120
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
146
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
146
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
4.3K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.3K