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Systemic immune-inflammation index predicts mortality in infective endocarditis
Hicaz Zencirkiran Agus1, Serkan Kahraman1, Cagdas Arslan1
1University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Journal of the Saudi Heart Association
|November 6, 2020
Summary
The systemic immune-inflammation index (SII) can predict in-hospital mortality in infective endocarditis patients. High SII levels indicate a higher risk, making it a valuable prognostic tool for this serious condition.
Area of Science:
- Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Infective endocarditis (IE) is a serious infection with significant in-hospital mortality.
- Predictive markers for mortality in IE patients are crucial for timely intervention.
Purpose of the Study:
- To evaluate the utility of the systemic immune-inflammation index (SII) upon admission for predicting in-hospital mortality in patients diagnosed with infective endocarditis.
Main Methods:
- Retrospective analysis of 133 definite IE patients (≥18 years) treated between December 2009 and May 2019.
- Data collected included clinical symptoms, comorbidities, echocardiography, and laboratory markers.
- Systemic immune-inflammation index (SII) calculated as: platelet count × neutrophil count/lymphocyte count at admission.
Main Results:
- In-hospital mortality was observed in 22% of patients, with renal failure being the next most frequent complication.
- Independent predictors of mortality included age, syncope, hypocalcemia, not undergoing surgery, and SII.
- An optimal SII cut-off value of 2314 was identified for predicting mortality (AUC = 0.641, P = 0.019).
Conclusions:
- Elevated SII levels are independently associated with increased in-hospital mortality in infective endocarditis patients.
- The SII demonstrates potential as a valuable and accessible prognostic predictor in this patient population.
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