A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy
Fuan Deng1, Guiling Fan, Ping Yuan
1Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P. R. China. lisy-sci@gzhmu.edu.cn.
Abstract:
A self-accelerated biocatalyst (Bio-Cat) was developed based on BSA and GOx crosslinked nanoproteins for glucose-initiated tumor starvation and chemodynamic therapy. Bio-Cat could catalyze the glucose to elevate the intracellular H2O2 level and accelerate the conversion of Fe3+/Fe2+, resulting in an effective starvation therapy and an accelerated Fenton reaction for chemodynamic therapy.
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