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Differential histopathological and immunohistochemical findings between palmar psoriasis and chronic hand eczema
Min Kyun An1, Ji Ha Yoon1, Eun Joo Park1
1Department of Dermatology.
Background:
The differential diagnosis between palmar psoriasis (PP), chronic hand dermatitis (CHE), and hyperkeratotic hand dermatitis (HHD) is challenging.
Objectives:
We sought to distinguish the histopathological and immunohistochemical characteristics between PP, CHD, and HHD.
Materials & Methods:
Hands, clinically diagnosed with PP, CHD, or HHD, were further evaluated using skin biopsy sections based on haematoxylin and eosin staining and immunohistochemical analysis for β-defensin 2 and interleukin-36γ.
Results:
Confluent parakeratosis, absent granular layer, and psoriasiform epidermal hyperplasia were more common in PP and HHD relative to CHE. The level of β-defensin 2 expression in the stratum corneum and interleukin-36γ in the stratum granulosum was higher in PP and HHD relative to CHD.
Conclusion:
Considering the similarities of histopathological and immunohistochemical findings, HHD may be an inflammatory disorder with a pathogenesis similar to that of PP, rather than CHD.
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