Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

9.2K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
9.2K
Notch Signaling Pathway03:14

Notch Signaling Pathway

5.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
5.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.9K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.9K
Tooth Anatomy01:21

Tooth Anatomy

1.7K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacological inhibition of frizzled 4 delays cell cycle progression and limits oral squamous cell carcinoma growth.

Frontiers in cell and developmental biology·2026
Same author

A microfluidic model of human dental pulp angiogenesis for preclinical drug and biomaterial testing.

Materials today. Bio·2026
Same author

"Dental Pulp-On-Chip" Microfluidic Devices for Emulating Human Dental Pulp Tissue Physiology and Pathology.

Journal of endodontics·2026
Same author

Mesenchymal stroma drives axonogenesis and nerve-induced aggressiveness in osteosarcoma.

Journal of experimental & clinical cancer research : CR·2025
Same author

Long-Term Biobanked Dental Pulp Stem Cells Retain Angiogenic Potential for Vascularised Tissue Engineering-Laboratory Investigation.

International endodontic journal·2025
Same author

An Innovative "Tooth-On-Chip" Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue.

Advanced healthcare materials·2025
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Related Experiment Video

Updated: Dec 1, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

3.9K

Exploiting teeth as a model to study basic features of signaling pathways.

Pierfrancesco Pagella1, Cristina Porcheri1, Thimios A Mitsiadis1

  • 1Orofacial Development and Regeneration, Institute of Oral Biology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.

Biochemical Society Transactions
|November 6, 2020
PubMed
Summary
This summary is machine-generated.

Teeth are valuable models for studying how signaling pathways control organ development and regeneration. This review highlights unique experimental approaches using teeth to understand cell and tissue interactions in health and disease.

Keywords:
developmental biologyepithelial–mesenchymal interactionsexperimental embryologysignaling pathwaysstem cellstooth

More Related Videos

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells
06:22

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Published on: July 8, 2021

2.6K
A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals
08:06

A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals

Published on: February 14, 2020

6.4K

Related Experiment Videos

Last Updated: Dec 1, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

3.9K
Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells
06:22

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Published on: July 8, 2021

2.6K
A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals
08:06

A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals

Published on: February 14, 2020

6.4K

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Teeth serve as a classical model for studying cell signaling in organogenesis, homeostasis, and regeneration.
  • Rodent teeth, particularly molars and incisors, are widely used experimental models for investigating epithelial-mesenchymal interactions and stem cell dynamics.

Purpose of the Study:

  • To review the use of teeth as a model system for investigating signaling pathways in biological processes.
  • To provide an overview of experimental approaches and models used in tooth biology research.
  • To introduce novel methods for studying complex interactions within dental tissues, including innervation and vascularization.

Main Methods:

  • Literature review of studies utilizing teeth as experimental models.
  • Analysis of established and emerging experimental approaches in tooth biology.
  • Discussion of signaling pathway modulation in tooth development, homeostasis, and regeneration.

Main Results:

  • Teeth offer unique experimental advantages for studying fundamental biological processes.
  • Complex signaling networks orchestrate various aspects of tooth biology, from development to regeneration.
  • New approaches enable the investigation of intricate crosstalk between dental tissues, innervation, and vascularization.

Conclusions:

  • Teeth are versatile models for unraveling signaling pathways critical to organ development, homeostasis, and regeneration.
  • Understanding these pathways in dental tissues provides insights into human diseases and regenerative strategies.
  • Future research directions include exploring complex tissue interactions using advanced experimental techniques.