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Related Experiment Video

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Using a Cell-Tracer Injection to Investigate the Origin of Neointima-Forming Cells in a Rat Saccular Side Wall Model
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Cellular responses to flow diverters in a tissue-engineered aneurysm model.

Wenjing Liu1,2, Daying Dai1, Yong-Hong Ding1

  • 1Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Journal of Neurointerventional Surgery
|November 7, 2020
PubMed
Summary

This study used a 3D tissue-engineered model to investigate cellular responses to flow diverters (FDs) in intracranial aneurysms. Results show progressive healing and cell coverage on FDs over 28 days, validating the model for device evaluation.

Keywords:
aneurysmdeviceflow diverter

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Area of Science:

  • Biomedical Engineering
  • Vascular Biology
  • Medical Device Research

Background:

  • Flow diverters (FDs) are widely used for intracranial aneurysms, but their precise mechanism of action requires further elucidation.
  • Understanding cellular responses to FD implantation is crucial for optimizing treatment outcomes.
  • Existing models may not fully replicate the complex biological environment of aneurysm treatment.

Purpose of the Study:

  • To investigate cellular responses to flow diverter (FD) implantation using a novel 3D tissue-engineered in vitro aneurysm model.
  • To characterize the healing process and cellular coverage on FDs over time.
  • To assess the utility of the developed model for evaluating endovascular aneurysm devices.

Main Methods:

  • Construction of aneurysm-like blood vessel mimics (aBVMs) using electrospun polycaprolactone nanofibers.
  • Seeding of aBVMs with human aortic smooth muscle cells (SMCs) and endothelial cells (ECs).
  • Deployment of FDs within the aBVMs and cultivation for 7, 14, and 28 days, followed by semi-quantitative measurement of cell coverage.

Main Results:

  • Partial endothelialization and cell coverage on FD struts and at the neck interface by day 7.
  • Formation of a neointimal-like lining by day 14, partially covering struts and pores.
  • Significant neointimal coverage of the aneurysm neck by day 28, with increased cellular coverage on struts and pores compared to earlier time points.

Conclusions:

  • The 3D tissue-engineered aneurysm model (aBVM) effectively simulates cellular responses to FD implantation.
  • Progressive healing and cellular coverage on FDs are demonstrated over a 28-day period.
  • aBVMs represent a valuable in vitro tool for evaluating the healing mechanisms of endovascular aneurysm devices.