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The relationship between childhood obesity with inflammatory mediators

Canan Eren1, Serpil Cecen2

  • 1Marmara University, Pendik Education and Research Hospital, Microbiology and Blood Center, Turkey.

JPMA. the Journal of the Pakistan Medical Association
|November 7, 2020
PubMed

Insights

Obesity markers like fat percentage are linked to increased inflammation in children. Systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) may serve as inflammatory biomarkers for monitoring obesity-related comorbidities.

Area of Science:

  • Pediatric Endocrinology
  • Immunology
  • Obesity Research

Background:

  • Obesity is a growing global health concern in children.
  • Systemic inflammation is increasingly recognized as a key factor in obesity-related complications.
  • Obesity markers require further investigation for their association with inflammatory indices.

Purpose of the Study:

  • To investigate the relationship between various obesity markers and the systemic immune-inflammatory index (SII) in children.
  • To identify potential inflammatory biomarkers for monitoring obesity and its comorbidities.

Main Methods:

  • A cross-sectional study involving 335 children (aged 6-16 years) with obesity.
  • Measurements included height, weight, BMI, fat percentage, fat mass, and waist circumference.
  • Haematological parameters were analyzed to calculate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII.

Main Results:

  • Fat percentage (F%) was a significant independent risk factor for SII in girls (p<0.01).
  • Fat mass (FM) was a significant independent risk factor for NLR in girls (p<0.01).
  • Other obesity markers like BMI and waist circumference did not show significant independent associations with NLR or SII in the multivariate model.

Conclusions:

  • Increased fat percentage and fat mass in obese children are associated with elevated systemic inflammation.
  • SII and NLR show potential as inflammatory biomarkers for tracking obesity-related comorbidities.
  • These findings highlight the role of fat accumulation in driving inflammation in pediatric obesity.
Abstract

Keywords:
Childhood obesity, Systemic immune inflammatory index, Neutrophil-to lymphocyte ratio, Fat mass.

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