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Bioinspired multifunctional adhesive system for next generation bio-additively designed dental restorations
Rizacan Sarikaya1, Linyong Song2, Esra Yuca3
1Institute for Bioengineering Research (IBER), University of Kansas (KU), 1530 W. 15th St, Lawrence, KS, 66045, USA; Department of Mechanical Engineering, University of Kansas (KU), 1530 W. 15th St, Lawrence, KS, 66045, USA.
New biohybrid dental adhesives tether peptides to polymers, offering antimicrobial and remineralization properties. This innovation aims to create durable seals, preventing recurrent decay at the composite/tooth interface for longer-lasting restorations.
Area of Science:
- Biomaterials Science
- Dental Materials
- Polymer Chemistry
Background:
- Resin-based composites are popular but have shorter lifespans than dental amalgam.
- Composite restoration failure is often due to marginal decay caused by fragile adhesive seals.
- Current adhesives lack antimicrobial properties, remineralization capabilities, and durable mechanical performance.
Purpose of the Study:
- To develop a next-generation dental adhesive system with enhanced durability and protective properties.
- To transition from hybrid to biohybrid adhesive structures.
- To create an adhesive that serves as a durable barrier against recurrent decay.
Main Methods:
- Tethering discrete peptides to polymers to create multi-bio-functional adhesive formulations.
- Designing bio-additive materials that combine antimicrobial and remineralization properties.
- Utilizing new polymer chemistries alongside peptide-polymer conjugates.
Main Results:
- Development of biohybrid adhesive formulations with simultaneous antimicrobial and remineralization capabilities.
- Creation of adhesives designed to provide a durable seal at the adhesive/dentin interface.
- Enhanced mechanical performance and repair of defective dentin.
Conclusions:
- The novel biohybrid adhesive system offers a promising solution to improve the longevity of dental restorations.
- Peptide-tethered polymers and advanced polymer chemistries are key to achieving enhanced antimicrobial and remineralization properties.
- This approach represents a significant advancement in dental adhesive technology, aiming to reduce restoration failure.
