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Updated: Dec 1, 2025
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Detecting urine metabolites of bladder cancer by surface-enhanced Raman spectroscopy
Dayu Hu1, Xiaosong Xu1, Zeyin Zhao1
1College of Medicine and Biological Information Engineering, Northeastern University, No. 500 Wisdom Street, Shenyang 110169, China.
Aim:
Metabolites present in urine reflect the current phenotype of the cancer state. Surface-enhanced Raman spectroscopy (SERS) can be used in urine supernatant or sediment to largely reflect the metabolic status of the body.
Materials & Methods:
SERS was performed to detect bladder cancer (BCa) and predict tumour grade from urine supernatant, which contains various system metabolites, as well as from urine sediment, which contains exfoliated tumour cells.
Results & Discussion:
Upon combining the urinary supernatant and sediment results, the total diagnostic sensitivity and specificity of SERS were 100% and 98.85%, respectively, for high-grade tumours and 97.53% and 90.80%, respectively, for low-grade tumours.
Conclusion:
The present results suggest high potential for SERS to detect BCa from urine, especially when combining both urinary supernatant and sediment results.
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