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Updated: Dec 1, 2025

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
[Corona in Children: the Co-Ki Study].
Silke Schwarz1, Ekkehart Jenetzky1,2, Hanno Krafft1
1Lehrstuhl für Medizintheorie, Integrative und Anthroposophische Medizin, Universität Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58448 Witten, Deutschland.
COVID-19 is rare in children presenting to outpatient pediatricians. This study found no strong evidence that children are a significant source of SARS-CoV-2 infection or at high risk.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Context:
- Over 80% of German children and adolescents receive care from registered pediatricians.
- Pediatricians offer a unique viewpoint on the COVID-19 pandemic's impact on child health.
Purpose:
- To investigate the prevalence and characteristics of SARS-CoV-2 infections in children from an outpatient pediatric perspective.
- To assess the role of children as a source of SARS-CoV-2 transmission and their risk of severe illness.
Summary:
- 557 pediatricians reported on 9803 suspected cases among ~670,000 children.
- PCR tests on 7707 children showed 2.6% positive for SARS-CoV-2; antibody tests on 731 children showed 11.2% positive.
- Few cases suggested children as a relevant source of adult infection, and COVID-19 appeared rare in this pediatric cohort.
Impact:
- Provides crucial data on pediatric COVID-19 from a real-world, ambulatory care setting.
- Informs public health strategies regarding pediatric infectious disease management and transmission dynamics.
- Highlights the low incidence of COVID-19 in children and their limited role as infection sources.
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