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Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Genome-wide Association Studies-GWAS

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Related Experiment Video

Updated: Dec 1, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Genomic Medicine: Lessons Learned From Monogenic and Complex Bone Disorders.

Katerina Trajanoska¹, Fernando Rivadeneira¹

¹Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands.

Frontiers in Endocrinology

|November 9, 2020

Summary

Genetic studies advance bone disease understanding, paving the way for personalized medicine and improved drug development. Genomic insights are revolutionizing skeletal disease diagnosis, prognosis, and treatment strategies.

Keywords:

Mendelian randomization complex diseases drug repurposing genomic medicine monogenic bone disorders osteoporosis

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Last Updated: Dec 1, 2025

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Area of Science:

Genetics and genomics
Skeletal biology
Pharmacology

Background:

Genetic studies have significantly advanced the understanding of monogenic and complex bone diseases.
This progress underscores the need for patient-specific medical interventions and treatments.

Purpose of the Study:

To review the achievements of genetic studies in the bone field.
To explore the application of genetic findings to clinical care.
To highlight the transition towards genomic medicine in skeletal disease management.

Main Methods:

Review of current genetic studies in bone diseases.
Analysis of the impact of genomic research on clinical decision-making.
Evaluation of genetic information in drug development.

Main Results:

Genomic research provides novel insights into molecular mechanisms of bone diseases.
Genetic support for drug targets increases the likelihood of success.
Genetic information aids in disease screening, diagnosis, prognosis, and treatment.

Conclusions:

Implementing genetic information can overcome shortcomings in pharmaceutical research.
Molecular redefinition of skeletal diseases is crucial.
The era of genomic medicine for skeletal diseases is imminent.