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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
16.9K
[Progress in dual-responsive nanocarriers based on acid sensitivity for anticancer drug]
Xiujuan Lu1, Xinhao Guo1, Dong Wan1
1School of Chemistry and Chemical Engineering, Tiangong University, Tianjin 300387, China.
Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|November 9, 2020
Summary
Researchers are developing smart nanocarriers for improved tumor treatment. These intelligent nanocarriers offer targeted drug delivery and reduced side effects, but face challenges in cost and complexity for clinical use.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Dual and multiple responsive smart nanocarriers are designed for enhanced tumor treatment within the tumor microenvironment.
- Acid-sensitive dual-responsive nanocarriers represent the most common and extensively researched type.
Purpose of the Study:
- To review recent advancements in dual-responsive nanocarriers for tumor therapy.
- To highlight various responsive combinations (acid-temperature, acid-magnetism, etc.) for nanomedicine.
Main Methods:
- Review of current research on smart nanocarriers.
- Analysis of dual-responsive mechanisms in the tumor microenvironment.
Main Results:
- Intelligent nanocarriers demonstrate prolonged circulation, tumor cell accumulation, and controlled drug release.
- These nanocarriers enhance anti-tumor effects while minimizing damage to normal tissues.
Conclusions:
- Despite progress, challenges like high cost, complex structures, and unclear delivery mechanisms impede clinical application.
- Further research into diverse dual-responsive nanocarriers is crucial for advancing nanomedicine in clinical settings.
