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COVID-19 during Pregnancy and Postpartum

Sreus A G Naidu1, Roger A Clemens2, Peter Pressman3

  • 1N-terminus Research Laboratory, Yorba Linda, CA, USA.

Journal of Dietary Supplements
|November 9, 2020
PubMed

Insights

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection during pregnancy poses risks to fetal development. Lactoferrin may offer protection, but cytokine storms can cause severe harm, highlighting the need for prevention.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Immunology

Background:

  • Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, presents unique challenges during pregnancy.
  • Increased oxidative stress in pregnancy may exacerbate COVID-19 severity.
  • Maternal-fetal interface redox changes and acute phase responses are amplified during pregnancy.

Purpose of the Study:

  • To review COVID-19 virulence factors and pathobiology in pregnancy and postpartum.
  • To elucidate the role of lactoferrin in mitigating COVID-19 effects during pregnancy.
  • To highlight the risks of uncontrolled inflammation on fetal neurodevelopment.

Main Methods:

  • Literature review of COVID-19 in pregnancy.
  • Analysis of oxidative stress and metabolic syndrome links to COVID-19.
  • Examination of lactoferrin's immunological functions.

Main Results:

  • Vertical transmission of SARS-CoV-2 is infrequent in COVID-19 pregnancy cases.
  • Lactoferrin presence in maternal-fetal compartments may inhibit transmission.
  • Cytokine storms in COVID-19 pregnancy can lead to fetal inflammatory damage and neurodevelopmental issues.

Conclusions:

  • COVID-19 prevention during pregnancy is a high priority due to potential severe fetal outcomes.
  • Lactoferrin offers potential immunological advantages against SARS-CoV-2 in pregnancy.
  • Further research is needed on lactoferrin's therapeutic potential in COVID-19 pregnancy.

Keywords:
coronavirus infectionsfemaleinfantlactoferrinpregnancy

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