COVID-19 during Pregnancy and Postpartum.
Sreus A G Naidu1, Roger A Clemens2, Peter Pressman3
1N-terminus Research Laboratory, Yorba Linda, CA, USA.
Journal of Dietary Supplements
|November 9, 2020
Summary
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection during pregnancy poses risks to fetal development. Lactoferrin may offer protection, but cytokine storms can cause severe harm, highlighting the need for prevention.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Immunology
Background:
- Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, presents unique challenges during pregnancy.
- Increased oxidative stress in pregnancy may exacerbate COVID-19 severity.
- Maternal-fetal interface redox changes and acute phase responses are amplified during pregnancy.
Purpose of the Study:
- To review COVID-19 virulence factors and pathobiology in pregnancy and postpartum.
- To elucidate the role of lactoferrin in mitigating COVID-19 effects during pregnancy.
- To highlight the risks of uncontrolled inflammation on fetal neurodevelopment.
Main Methods:
- Literature review of COVID-19 in pregnancy.
- Analysis of oxidative stress and metabolic syndrome links to COVID-19.
- Examination of lactoferrin's immunological functions.
Main Results:
- Vertical transmission of SARS-CoV-2 is infrequent in COVID-19 pregnancy cases.
- Lactoferrin presence in maternal-fetal compartments may inhibit transmission.
- Cytokine storms in COVID-19 pregnancy can lead to fetal inflammatory damage and neurodevelopmental issues.
Conclusions:
- COVID-19 prevention during pregnancy is a high priority due to potential severe fetal outcomes.
- Lactoferrin offers potential immunological advantages against SARS-CoV-2 in pregnancy.
- Further research is needed on lactoferrin's therapeutic potential in COVID-19 pregnancy.
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