COVID-19 during Pregnancy and Postpartum.
Sreus A G Naidu1, Roger A Clemens2, Peter Pressman3
1N-terminus Research Laboratory, Yorba Linda, CA, USA.
Journal of Dietary Supplements
|November 9, 2020
Summary
Pregnancy with COVID-19 generally results in mild illness, with natural barriers deterring mother-to-child virus transmission. Lactoferrin (LF) shows potential in preventing SARS-CoV-2 infection and reducing pregnancy complications.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Immunology
Background:
- The COVID-19 pandemic presents risks for pregnant individuals, including potential vertical transmission of SARS-CoV-2.
- While most COVID-19 pregnancies are mild, increased hypoxia-induced preterm deliveries are observed.
- Natural maternal defenses appear to limit SARS-CoV-2 transmission to neonates.
Purpose of the Study:
- To investigate the maternal-fetal interface for innate defense factors against SARS-CoV-2.
- To explore the role of lactoferrin (LF) in mitigating COVID-19-related pregnancy complications.
Main Methods:
- Review of clinical observations regarding COVID-19 in pregnancy.
- Analysis of the known antiviral properties of lactoferrin (LF) and its mechanisms of action.
- Exploration of LF's potential interaction with the ACE2 receptor.
Main Results:
- Pregnancy and postpartum periods exhibit natural barriers against SARS-CoV-2 transmission.
- Lactoferrin (LF) is present at the maternal-fetal interface and possesses potent antiviral properties.
- LF may down-regulate ACE2, potentially limiting SARS-CoV-2 cellular entry and reducing hypertension risks.
Conclusions:
- Understanding innate factors like LF is crucial for preventing SARS-CoV-2 vertical transmission and associated comorbidities in pregnancy.
- LF and its derived peptides demonstrate potential in blocking viral entry and infection.
- Further research into LF and milk-derived factors could lead to novel nutraceutical interventions for COVID-19-Pregnancy.
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