Minimally Invasive Approaches in Locally Advanced Cervical Cancer Patients Undergoing Radical Surgery After...

Area of Science:

• Gynecologic Oncology
• Surgical Oncology
• Radiation Oncology

Background:

• Chemoradiation (CT/RT) followed by radical surgery (RS) is a treatment option for locally advanced cervical cancer (LACC).
• Minimally invasive radical surgery (MI-RS) and open radical surgery (O-RS) are surgical modalities for LACC.
• Evaluating oncological and surgical outcomes is crucial for treatment selection.

Purpose of the Study:

• To compare the oncological and surgical outcomes of MI-RS versus O-RS in LACC patients.
• To assess disease-free survival (DFS), locoregional recurrence, and disease-specific survival (DSS).
• To evaluate postoperative complications and length of hospital stay.

Main Methods:

• Retrospective analysis of stage IB2-IVA cervical cancer patients treated with CT/RT and RS.
• Propensity score matching was used to balance patient characteristics between MI-RS and O-RS groups.
• Oncological outcomes (DFS, recurrence, DSS) and surgical outcomes (complications, blood loss, hospital stay) were analyzed.

Main Results:

• No significant difference in 5-year DFS (73.7% O-RS vs. 73.0% MI-RS) or DSS (80.4% O-RS vs. 85.3% MI-RS).
• Locoregional recurrence rates were similar between O-RS (12.5%) and MI-RS (15.2%).
• MI-RS demonstrated significantly lower estimated blood loss and shorter hospital stay, with comparable rates of early and late postoperative complications.

Conclusions:

• MI-RS and O-RS yield similar oncological results for LACC patients post-CT/RT.
• Both surgical approaches are associated with comparable rates of recurrence and death.
• No significant difference in early or late postoperative complications was observed between MI-RS and O-RS.