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Updated: Dec 1, 2025

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
Published on: August 18, 2023
The interplay between cancer type, panel size and tumor mutational burden threshold in patient selection for cancer
Mahdi Golkaram1, Chen Zhao1, Kristina Kruglyak1
1Illumina, Inc., San Diego, CA, United States of America.
Abstract:
The tumor mutational burden (TMB) is increasingly recognized as an emerging biomarker that predicts improved outcomes or response to immune checkpoint inhibitors in cancer. A multitude of technical and biological factors make it difficult to compare TMB values across platforms, histologies, and treatments. Here, we present a mechanistic model that explains the association between panel size, histology, and TMB threshold with panel performance and survival outcome and demonstrate the limitations of existing methods utilized to harmonize TMB across platforms.
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