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Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis-A Systematic Review and Meta-Analysis
Chen-Chi Wang1,2,3,4, Shang-Heng Wu4, Yu-Kang Tu5
1School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Cells
|November 10, 2020
Summary
Hyaluronic acid (HA) injection laryngoplasty (IL) effectively treats unilateral vocal fold paralysis (UVFP), improving voice quality and swallowing function. This minimally invasive procedure offers a potentially long-term solution, reducing the need for permanent surgical interventions.
Area of Science:
- Otolaryngology
- Speech and Hearing Science
- Regenerative Medicine
Background:
- Unilateral vocal fold paralysis (UVFP) impairs glottal closure, leading to voice hoarseness and swallowing difficulties.
- Current treatments for UVFP range from conservative management to surgical interventions like thyroplasty.
- Hyaluronic acid (HA) injection laryngoplasty (IL) has emerged as a less invasive therapeutic option.
Purpose of the Study:
- To systematically review and meta-analyze the efficacy of HA injection laryngoplasty (IL) for treating patients with unilateral vocal fold paralysis (UVFP).
- To evaluate the impact of HA IL on voice quality of life, perceptual voice assessments, and objective voice parameters.
Main Methods:
- A systematic literature search was conducted across PubMed, EBSCO Medline, and Cochrane Library databases.
- Fourteen studies meeting predefined inclusion criteria were included in a random-effect meta-analysis.
- Outcomes assessed included voice-related quality of life, perceptual evaluations, maximal phonation time, and glottal gap area.
Main Results:
- HA IL demonstrated significant improvements in glottal closure insufficiency in UVFP patients.
- Maximal phonation time was prolonged, and perceptual voice evaluations and quality of life scores improved post-treatment.
- The duration of treatment effects varied across studies, indicating a need for further investigation into long-term outcomes.
Conclusions:
- Hyaluronic acid (HA) injection laryngoplasty (IL) is an effective treatment for unilateral vocal fold paralysis (UVFP).
- HA IL offers a promising alternative that can improve voice and swallowing function, potentially reducing the need for permanent medialization thyroplasty.
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