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Updated: Dec 1, 2025
08:18
Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
17.6K
Cellular Senescence in Renal and Urinary Tract Disorders
Yohan Santin1, Philippe Lluel2, Pascal Rischmann3
1Institut des Maladies Métaboliques et Cardiovasculaires, Inserm, Université Paul Sabatier, UMR 1048-I2MC, 31432 Toulouse, France.
Cells
|November 10, 2020
Summary
Cellular senescence, a cell cycle arrest state, offers benefits in repair but causes harm when persistent. Targeting senescent cells may treat renal and urinary tract disorders.
Area of Science:
- Cellular and Molecular Biology
- Pathology
- Urology
Background:
- Cellular senescence is a state of cell cycle arrest with dual roles in health and disease.
- Persistent senescent cells contribute to chronic inflammation and tissue damage, particularly in renal and urinary tract disorders.
- The senescence-associated secretory phenotype (SASP) is a key driver of detrimental effects.
Purpose of the Study:
- To review the molecular mechanisms of cellular senescence.
- To elucidate the role of senescence in renal and urinary tract diseases.
- To discuss the therapeutic potential of targeting senescent cells.
Main Methods:
- Literature review of molecular mechanisms of senescence.
- Analysis of studies investigating senescent cells in renal, prostate, and bladder disorders.
- Discussion of transient versus persistent senescence and therapeutic strategies.
Main Results:
- Transient senescence aids tissue repair and tumor suppression.
- Persistent senescence is linked to chronic diseases, including renal/urinary tract disorders.
- Senescent cell accumulation and SASP exacerbate inflammation and fibrosis.
Conclusions:
- Cellular senescence has complex roles, with persistent accumulation being detrimental in urogenital diseases.
- Understanding the differential impact of senescence states is crucial.
- Targeting senescent cells presents a promising therapeutic avenue for these conditions.
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