AKR1C1 Contributes to Cervical Cancer Progression via Regulating TWIST1 Expression

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Updated: Dec 1, 2025

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

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Xing Wei1, Zhongheng Wei2, Yueyong Li3

  • 1Department of Biochemistry and Molecular Biology, YouJiang Medical University for Nationalities, Baise City, 533000, Guangxi Zhuang Autonomous Region, China.

Biochemical Genetics
|November 10, 2020
PubMed

Insights

Aldo-keto reductase 1 family member C1 (AKR1C1) is highly expressed in cervical cancer (CC) tissues and promotes CC cell proliferation and invasion. AKR1C1 may serve as a potential molecular target for CC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cervical cancer (CC) is a significant gynecological malignancy with ongoing needs for novel therapeutic targets.
  • Targeted therapies offer advantages, but effective strategies require identifying key molecular drivers.
  • Aldo-keto reductase 1 family member C1 (AKR1C1) is implicated in various tumors but its role in CC is not fully understood.

Purpose of the Study:

  • To investigate the expression and function of AKR1C1 in cervical cancer.
  • To determine the potential of AKR1C1 as a therapeutic target for CC.

Main Methods:

  • Analysis of AKR1C1 expression in human CC tissues.
  • In vitro experiments assessing the impact of AKR1C1 on CC cell proliferation and invasion.
  • Investigation of AKR1C1's regulatory effects on TWIST1 expression and the AKT pathway.

Main Results:

  • AKR1C1 was found to be highly expressed in human CC tissues.
  • High AKR1C1 expression correlated with patient clinical characteristics.
  • AKR1C1 significantly regulated the proliferation and invasion of cervical cancer cells.
  • AKR1C1 influences TWIST1 expression and the AKT signaling pathway.

Conclusions:

  • AKR1C1 plays a crucial role in the progression of cervical cancer.
  • AKR1C1 demonstrates potential as a novel molecular target for CC therapy.
Keywords:
Aldo-keto reductase 1 family member C1 (AKR1C1)Cervical cancer (CC)InvasionMolecular targetProliferation

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