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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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The European Nucleotide Archive in 2020.

Peter W Harrison1, Alisha Ahamed1, Raheela Aslam1

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The European Nucleotide Archive (ENA) offers free public sequencing data. Key 2020 updates include an improved browser, streamlined release processes, and enhanced research community collaborations for global scientific advancement.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • The European Nucleotide Archive (ENA) has served the scientific community for nearly forty years.
  • It provides free access to public sequencing data, supporting global research efforts.
  • The European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) manages the ENA.

Purpose of the Study:

  • To highlight major developments in ENA services and content during 2020.
  • To showcase improvements in data accessibility and management.
  • To emphasize ENA's role in coordinating data for research communities.

Main Methods:

  • Development and release of an updated ENA browser interface.
  • Modernization of the ENA data release process.
  • Strengthening data coordination collaborations with various research communities.

Main Results:

  • An improved ENA browser enhancing data discovery and access.
  • A more efficient and modernized data release workflow.
  • Strengthened partnerships facilitating better data integration for research.

Conclusions:

  • ENA continues its mission to provide essential sequencing data resources.
  • Recent updates enhance user experience and data management efficiency.
  • Collaborative efforts with research communities improve data utility and accessibility.