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The interrelationship between diabetes mellitus and peripheral arterial disease
Konstanze Stoberock1, Mark Kaschwich1, Shiva Sophia Nicolay1
1Department of Vascular Medicine, Research Group GermanVasc, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
VASA. Zeitschrift Fur Gefasskrankheiten
|November 11, 2020
Summary
This systematic review highlights the significant link between diabetes mellitus (DM) and peripheral arterial disease (PAD). Diabetic patients with PAD experience worse outcomes, emphasizing the need for early detection in both conditions.
Area of Science:
- Vascular Surgery
- Endocrinology
- Public Health
Background:
- Peripheral arterial disease (PAD) and diabetes mellitus (DM) frequently coexist.
- Understanding their interrelationship is crucial for patient outcomes.
Purpose of the Study:
- To systematically review and compare the prevalence and outcomes of PAD in patients with and without DM.
- To identify differences in PAD presentation and management between diabetic and non-diabetic populations.
Main Methods:
- Systematic review of literature from 2007-2020, including guidelines, reviews, and observational studies.
- Search encompassed German and English literature on symptomatic PAD and DM in patients undergoing revascularization.
- Data from 61 studies involving 850,072 patients were analyzed.
Main Results:
- PAD prevalence is higher in diabetic populations (20-50%) compared to non-diabetic (10-26%).
- Diabetic patients with PAD exhibit worse perioperative complications, higher amputation rates, and increased mortality.
- Amputation rates declined in both groups over the study period.
Conclusions:
- A strong interrelationship exists between PAD and DM, impacting patient outcomes.
- Early detection of PAD in diabetic patients, and DM in PAD patients, is recommended to improve results.
- Findings can inform updates to clinical practice guidelines for managing PAD and DM.
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