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Updated: Dec 1, 2025

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

Oral Microbiota and Cancer Development.

Heidi Tuominen^1,2, Jaana Rautava^3,4

¹Department of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology

|November 11, 2020

Summary

Oral bacteria, especially Porphyromonas gingivalis, are linked to cancer development. This review explores the mechanisms by which oral microbiota contribute to cancer and disease progression.

Keywords:

Bacteria Cancer Carcinoma Microbiome Microbiota Mucosa Oral cancer Oral cavity

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Published on: June 13, 2020

Area of Science:

Microbiology
Oncology
Oral Health

Background:

The oral cavity hosts diverse bacterial communities, exceeding 700 identified species.
Unique oral anatomy influences microbiota composition.
Emerging research links oral microbiota to systemic diseases, including cancer.

Purpose of the Study:

To review the current understanding of oral bacterial microbiota's role in cancer development.
To elucidate the mechanisms by which oral bacteria contribute to carcinogenesis.

Main Methods:

Literature review of studies investigating oral microbiota and cancer.
Analysis of mechanisms of bacterial carcinogenicity.
Examination of associations between periodontitis and cancer risk.

Main Results:

Periodontitis patients exhibit a 2-5 times higher cancer risk.
Specific oral bacteria like Porphyromonas gingivalis and Fusobacterium nucleatum possess carcinogenic potential.
Mechanisms include inhibiting apoptosis, promoting proliferation and invasion, inducing inflammation, and producing carcinogens.

Conclusions:

Oral microbiota play a significant role in cancer development.
Understanding these complex interactions is crucial for cancer prevention and treatment strategies.
Further research is needed to clarify the causal relationship in humans.