Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune responses in the central nervous system.

D E Griffin1, J L Hess, T R Moench

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Toxicologic Pathology
|January 1, 1987
PubMed
Summary

The central nervous system (CNS) mounts unique immune responses involving T and B lymphocytes, monocytes, and natural killer cells. These responses can target viral infections or normal CNS tissue, leading to inflammation and demyelination.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why is there selective subcortical vulnerability in ADHD? Clues from postmortem brain gene expression data.

Molecular psychiatry·2017
Same author

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia.

Psychological medicine·2017
Same author

Genetics of Schizophrenia: Historical Insights and Prevailing Evidence.

Advances in genetics·2016
Same author

A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples.

Molecular psychiatry·2015
Same author

Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets.

Oncogene·2015
Same author

Myocardial extramedullary hematopoiesis following myocardial infarction.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015

Area of Science:

  • Neuroimmunology
  • Central Nervous System (CNS) Immunity

Background:

  • CNS immune responses are distinct due to its unique cellular organization and the blood-brain barrier.
  • Viral infections of the CNS involve T and B lymphocytes, monocytes, and natural killer cells.

Purpose of the Study:

  • To elucidate the cellular players and mechanisms of immune responses within the CNS.
  • To differentiate immune responses to viral infections versus autoimmune attacks on CNS tissue.

Main Methods:

  • Analysis of immune cell populations (T lymphocytes, B lymphocytes, monocytes, NK cells) in CNS tissue and cerebrospinal fluid (CSF).
  • Characterization of immune-mediated pathology, including vasculitis and demyelination.

Main Results:

  • Helper/inducer T lymphocytes are typically predominant in CSF and perivascular areas, orchestrating responses via lymphokines.

Related Experiment Videos

  • Cytotoxic/suppressor T lymphocytes are prominent in immunopathologic reactions.
  • Immune responses targeting normal CNS tissue can manifest as vasculitis (immune complex-mediated) or perivascular demyelination (macrophage-mediated).

    • Conclusions:

    • CNS immune responses are complex, involving diverse cell types and pathways.
    • Demyelination may be driven by macrophages sensitized to myelin, potentially directed by lymphokines or immunoglobulins.
    • Understanding these mechanisms is crucial for addressing CNS inflammatory and autoimmune diseases.