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Clinical syndrome of childhood asthma based on key indicators detection

Junfang Feng1, Chunlan Cao2, Xiaoyan Xu3

  • 1Department of Paediatrics, Dezhou People's Hospital, Dezhou, Shandong Province, China.

JPMA. the Journal of the Pakistan Medical Association
|November 12, 2020
PubMed

Insights

Pediatric asthma involves specific clinical indicators, with male children aged 2-5 most affected. Elevated D-dimer and fibrinogen levels are linked to acute asthma, suggesting potential diagnostic markers.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Medicine
  • Traditional Chinese Medicine (TCM)

Background:

  • Asthma is a common chronic respiratory disease in children, characterized by recurrent episodes of wheezing, coughing, and shortness of breath.
  • Understanding the clinical manifestations and underlying pathological mechanisms of pediatric asthma is crucial for effective management.
  • Traditional Chinese Medicine (TCM) offers a unique perspective on classifying and treating asthma syndromes.

Purpose of the Study:

  • To investigate the clinical syndromes of childhood asthma using key indicators.
  • To analyze the relationship between clinical symptoms, biochemical markers, and etiological factors in pediatric asthma.
  • To explore the potential of integrating TCM diagnostic principles with Western medicine approaches for asthma management.

Main Methods:

  • A cohort of 50 children diagnosed with asthma was studied.
  • Clinical symptoms (cough, wheezing, sputum) and physical signs were assessed.
  • Plasma levels of D-dimer (DD) and fibrinogen (Fg) were measured, alongside blood gas analysis.
  • Diagnostic symptoms were categorized using both TCM diagnostic statistics and Western medicine scoring systems.

Main Results:

  • Male children and those aged 2-5 years were predominantly affected.
  • Significantly increased plasma levels of D-dimer (DD) and fibrinogen (Fg) were observed in children with acute asthma.
  • A history of allergy and family inheritance were closely associated with asthma onset.
  • Respiratory tract infections, particularly from cold air exposure, were identified as a primary trigger.
  • Common clinical presentations included fever, moderate to severe cough, and sputum production.
  • Identified TCM syndromes included wind-heat, lung-qi deficiency, and wind-cold.

Conclusions:

  • Asthma in children presents with distinct clinical and biochemical profiles.
  • Elevated DD and Fg levels may serve as indicators for acute pediatric asthma.
  • Allergies, family history, and respiratory infections are significant risk factors.
  • The identified TCM syndromes provide a framework for targeted prevention, diagnosis, and treatment strategies in pediatric asthma.

Keywords:
Childhood Asthma, Clinical Syndromes, Detection of Traditional Chinese and Western Medicine.

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