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Pediatric bowel preparation: Sodium picosulfate, magnesium oxide, citric acid vs polyethylene glycol, a randomized

Carmen Cuffari1, Steven L Ciciora2, Masakazu Ando3

  • 1Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, MD 21287, United States. ccuffari@jhmi.edu.

World Journal of Gastroenterology
|November 12, 2020
PubMed

Insights

Sodium picosulfate, magnesium oxide, and citric acid (SPMC) is an effective and safe bowel preparation for children aged 9-16. This new option demonstrated higher tolerability compared to polyethylene glycol (PEG).

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Trial Research
  • Pharmacology

Background:

  • Bowel preparation in pediatric patients presents unique challenges.
  • Effective and safe methods are crucial for successful colonoscopy in children.

Purpose of the Study:

  • To evaluate the efficacy, safety, and tolerability of sodium picosulfate, magnesium oxide, and citric acid (SPMC) for bowel preparation in children aged 9-16 years.
  • To compare SPMC with polyethylene glycol (PEG)-based preparations.

Main Methods:

  • A phase 3, randomized, assessor-blinded, multicenter study involving 78 children aged 9-16.
  • Participants were randomized to receive different doses of SPMC or PEG.
  • Bowel preparation quality was assessed using the modified Aronchick Scale; tolerability and satisfaction were measured via questionnaire.

Main Results:

  • SPMC demonstrated comparable efficacy to PEG in achieving adequate bowel preparation across age groups.
  • Participants receiving SPMC (1 dose x 2) reported significantly higher ease of drinking compared to PEG.
  • Treatment-emergent adverse events were less frequent with SPMC compared to PEG.

Conclusions:

  • SPMC is an efficacious and safe bowel preparation option for pediatric patients undergoing colonoscopy.
  • SPMC offers improved tolerability over PEG, enhancing patient experience.
  • This study supports SPMC as a viable alternative for pediatric bowel preparation.
Abstract

Keywords:
ChildrenColon cleansingColonoscopyPolyethylene glycolSodium picosulfate, magnesium oxide, and citric acid

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