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Stem cell-based therapies for fertility preservation in males: Current status and future prospects

Han-Chao Liu1, Yun Xie1, Chun-Hua Deng1

  • 1Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.

World Journal of Stem Cells
|November 12, 2020
PubMed

Insights

Male fertility preservation is advancing with stem cell therapies. Research highlights spermatogonial stem cells, their niches, organoids, and extracellular vesicles for future fertility treatments.

Area of Science:

  • Reproductive biology and stem cell science.

Background:

  • Declining male fertility rates necessitate innovative preservation strategies.
  • Stem cell-based approaches are emerging as promising solutions for male infertility.

Purpose of the Study:

  • To review current research and future directions in stem cell-based male fertility preservation.
  • To focus on spermatogonial stem cells (SSCs) and related technologies.

Main Methods:

  • Comprehensive review of current treatments and recent scientific publications.
  • Analysis of stem cell types and their applications in fertility preservation.

Main Results:

  • Spermatogonial stem cells (SSCs), SSC niches, and SSC-based testicular organoids are key areas of research.
  • Mesenchymal stem cells and stem cell-derived extracellular vesicles also show potential.

Conclusions:

  • Understanding the germ cell microenvironment is crucial for advancing male fertility preservation.
  • Stem cell-derived extracellular vesicles and testicular organoids are vital for future success.
Keywords:
Extracellular vesiclesFertility preservationSperm cryopreservationSpermatogonial stem cellStem cellTesticular organoids

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