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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Updated: Nov 30, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Metastatic Squamous Cell Carcinoma: A Cautionary Tale.

Colby Shreve1, Chase Shropshire1, David G Cotter1

  • 1Dermatology, University of Nevada Las Vegas School of Medicine, Las Vegas, USA.

Cureus
|November 12, 2020
PubMed
Summary

Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer. This case highlights a rare metastatic cSCC presenting as a cyst, emphasizing the importance of thorough evaluation for accurate diagnosis and treatment.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer in the United States.
Keywords:
cutaneous malignancycutaneous metastasishigh risk sccmetastatic skin cancermohs surgerysolitary metastasissquamous cell carcinoma (scc)

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  • It typically affects older Caucasian men and is linked to risk factors like UV exposure and immunosuppression.
  • While metastasis is rare, tumor characteristics are crucial for risk stratification.