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Updated: Nov 30, 2025

Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing
Published on: March 22, 2019
Selective detection of complex gas mixtures using point contacts: concept, method and tools
Alexander P Pospelov1, Victor I Belan2, Dmytro O Harbuz1,2
1Department of Physical Chemistry, National Technical University "Kharkiv Polytechnic Institute", 2 Kyrpychov Str., Kharkiv, 61002, Ukraine.
Quantum point-contact sensors offer unique real-time gas mixture analysis. This novel approach analyzes human breath, enabling non-invasive detection of biomarkers like serotonin and cortisol.
Area of Science:
- Quantum physics and nanosensor technology.
- Development of novel sensing principles for complex gas mixtures.
Background:
- Conventional conductance-based nanosensors have limitations.
- Yanson point contacts possess unique quantum properties suitable for advanced sensing applications.
Purpose of the Study:
- To demonstrate the capability of quantum point-contact sensors for selective, real-time detection of gas mixture components.
- To showcase the application of these sensors in analyzing complex biological gas mixtures, specifically human breath.
Main Methods:
- Utilizing Yanson point contacts as sensing elements in point-contact sensors.
- Analyzing human breath as a complex gas mixture to obtain a spectroscopic profile.
- Correlating sensor output signals with the concentrations of specific breath components, such as serotonin and cortisol.
Main Results:
- Quantum point-contact sensors can selectively detect gas mixture components in real time.
- A spectroscopic profile of human breath was obtained, revealing energy interactions during adsorption/desorption.
- An effective calibration function was developed for non-invasive analysis of serotonin and cortisol levels via a point-contact breath test.
Conclusions:
- Quantum point-contact sensors provide a powerful tool for analyzing complex gas mixtures.
- The developed methodology enables non-invasive, real-time monitoring of biomarkers in human breath.
- This technology has significant potential for applications in medicine and other scientific fields.
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