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5-HT3 SEROTONIN RECEPTOR BLOCKERS FOR INTENSIVE THERAPY OF TRAUMATIC DISEASE IN PATIENTS WITH MULTIPLE TRAUMA
Yuliya V Volkova1, Kostiantyn G Mykhnevych1, Volodymyr I Ponomaryov2
1KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|January 2, 2023
Summary
Osetron provides superior antiemetic effects in polytrauma patients, especially those with cranio-abdominal injuries, compared to metoclopramide. This drug is a rational choice for managing nausea and vomiting in critical trauma care.
Area of Science:
- Emergency Medicine
- Pharmacology
- Trauma Surgery
Background:
- Nausea and vomiting are common in polytrauma patients.
- Effective antiemetic management is crucial for patient recovery.
- Existing treatments may have limitations in severe trauma cases.
Purpose of the Study:
- To determine the most effective antiemetic drug for polytrauma patients.
- To compare the efficacy of osetron and metoclopramide in this population.
- To evaluate the role of antiemetics in the acute and early phases of polytrauma.
Main Methods:
- A study involving 82 polytrauma patients (62 male, 20 female).
- Patients were divided into a main group (36) and a control group (46).
- Groups were comparable in demographics, injury severity, and time to admission.
Main Results:
- Osetron achieved a 96.3% complete antiemetic effect.
- Metoclopramide achieved a 72.4% full antiemetic effect.
- Osetron also demonstrated anxiolytic effects without sedation, aiding in trauma management.
Conclusions:
- Antiemetic drug use is vital in polytrauma treatment.
- Osetron is a rational and highly effective choice for polytrauma patients.
- Osetron is particularly recommended for polytrauma patients with cranio-abdominal injuries.
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