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Association Study of FOXO3a Single-Nucleotide Polymorphism and Bronchial Asthma in Egyptian Children

Rasha A Khattab1, Heba M Ahmed2, Noha A Doudar1

  • 1Department of Clinical & Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

The Egyptian Journal of Immunology
|November 12, 2020
PubMed

Insights

Egyptian children with the mutant TT genotype in the FOXO3 gene have an increased risk of developing childhood asthma, particularly males. This genetic factor contributes to asthma pathogenesis.

Area of Science:

  • Genetics
  • Pediatrics
  • Respiratory Medicine

Background:

  • Asthma is a prevalent chronic childhood illness, a major cause of hospitalizations and school absences.
  • Asthma phenotypes vary based on genetics, environment, and epigenetics.
  • The FOXO3 gene, encoding a transcription factor, is implicated in inflammatory and respiratory diseases.

Purpose of the Study:

  • To investigate the association between the FOXO3 gene SNP rs13217795 and pediatric asthma in Egyptians.
  • To determine if specific genotypes of FOXO3 influence asthma risk in children.

Main Methods:

  • Genotyping of 90 asthmatic children and 160 healthy controls for FOXO3 SNP rs13217795.
  • Utilized the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique.
  • Analyzed genotype frequencies and their association with asthma using statistical models.

Main Results:

  • The mutant homozygous (TT) genotype of FOXO3 SNP rs13217795 was significantly more prevalent in asthmatic children (33.3%) compared to controls (17.5%) (P=0.039).
  • This association was particularly strong in males, with an Odds Ratio of 5.3 (P=0.01).
  • No significant difference was found for homozygous (CC) and heterozygous (CT) genotypes.

Conclusions:

  • The TT genotype of FOXO3 SNP rs13217795 is a risk factor for pediatric asthma in the Egyptian population.
  • Male children carrying the TT genotype exhibit a heightened susceptibility to developing asthma.
  • FOXO3 genetic variations play a role in childhood asthma development.

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