Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI-Based Pressure Gradient Mapping in Patient-Specific Models of Coarctation of the Aorta.

medRxiv : the preprint server for health sciences·2026
Same author

Diffusion-weighted Imaging of the Liver: Primed for New Business.

Radiology·2026
Same author

Personalized biventricular mechanics and sensitivity to model morphology.

bioRxiv : the preprint server for biology·2025
Same author

Toward Modality- and Sampling-Universal Learning Strategies for Accelerating Cardiovascular Imaging: Summary of the CMRxRecon2024 Challenge.

IEEE transactions on medical imaging·2025
Same author

The Effect of Voxel Volume and Voxel Shape on Cardiac Diffusion Tensor Imaging Metrics.

Magnetic resonance in medicine·2025
Same author

Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models.

PLoS computational biology·2025

Related Experiment Video

Updated: Nov 30, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

3.5K

Probing cardiomyocyte mobility with multi-phase cardiac diffusion tensor MRI.

Kévin Moulin1,2, Ilya A Verzhbinsky1,2, Nyasha G Maforo2,3

  • 1Department of Radiology, Stanford University, Stanford, CA, United States of America.

Plos One
|November 12, 2020
PubMed
Summary
This summary is machine-generated.

Cardiac diffusion tensor imaging (cDTI) reveals cardiomyocyte mobility during the cardiac cycle. Healthy volunteers show longitudinal cardiomyocyte reorientation during contraction and radial tilting during wall thickening, offering new insights into myocardial microstructure.

More Related Videos

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

6.9K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.7K

Related Experiment Videos

Last Updated: Nov 30, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

3.5K
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

6.9K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.7K

Area of Science:

  • Cardiovascular Imaging
  • Biophysics
  • Cardiac Mechanics

Background:

  • Cardiomyocyte organization is crucial for cardiac function.
  • Probing in vivo cardiomyocyte mobility during the cardiac cycle is challenging.
  • Novel imaging techniques are needed to understand myocardial microstructure dynamics.

Purpose of the Study:

  • To characterize cardiomyocyte organization and mobility throughout the cardiac cycle in healthy volunteers.
  • To evaluate a novel trigger delay (TD) scout sequence for cardiac diffusion tensor imaging (cDTI).
  • To assess high in-plane resolution cDTI for probing myocardial microstructure.

Main Methods:

  • Nine healthy volunteers underwent free-breathing Spin-Echo (SE) cDTI at 3T.
  • High-resolution images (1.6x1.6x8mm3) were acquired at three cardiac phases: early systole, late systole, and diastasis.
  • Parameters like Helix Angle Range (HAR) and E2 angle (E2A) were characterized in the left ventricle.

Main Results:

  • SE cDTI acquisition was successful in a high percentage of cases across cardiac phases.
  • Significant changes in cardiomyocyte mobility were observed between cardiac phases.
  • Helix Angle Range (HAR) increased from early to late systole (p<0.001), and E2 angle (E2A) varied significantly across phases (p<0.001).

Conclusions:

  • Multi-phase, high-resolution cDTI can successfully probe cardiomyocyte mobility.
  • In healthy hearts, cardiomyocytes re-orient longitudinally during contraction.
  • Cardiomyocyte sheetlets exhibit radial tilting during systolic wall thickening, providing new insights into myocardial dynamics.