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Immune system: development and acquisition of immunological competence
Maria Isabel de Moraes-Pinto1, Fabíola Suano-Souza2, Carolina S Aranda3
1Universidade Federal de São Paulo, Departamento de Pediatria, Disciplina de Infectologia Pediátrica, São Paulo, SP, Brazil.
Jornal De Pediatria
|November 12, 2020
Summary
This review details the neonatal immune system
Area of Science:
- Immunology
- Neonatal Development
- Maternal-Fetal Health
Background:
- Recent advances have significantly improved understanding of immune system development from conception.
- New investigation tools offer insights into previously poorly understood phenomena.
- Ongoing research explores maternal-fetal exchanges, microbiota interactions, and immunological competence acquisition.
Purpose of the Study:
- To describe the ontogeny of the immune system in neonates.
- To detail adaptive immune mechanisms during the neonatal period.
- To emphasize transplacental antibody transport and breastfeeding's role.
Main Methods:
- Non-systematic literature review.
- PubMed database search.
Main Results:
- Significant advancements in understanding immune system development since conception.
- Improved insight into maternal-fetal exchanges and microbiota influence.
- Enhanced understanding of immunological competence acquisition in neonates.
Conclusions:
- In-depth knowledge of neonatal immune development is crucial.
- Understanding adaptive mechanisms aids in optimizing maternal and infant vaccination strategies.
- This knowledge supports postnatal development, early diagnosis, and treatment of immune disorders.
Keywords:
BreastfeedingHost-pathogen interactionsImmune systemImmunocompetenceMaternal-fetal relationsVaccinationMore Related Videos
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