DEA Disconnect Leads to Buprenorphine Bottlenecks
Related Experiment Video
Updated: Nov 30, 2025

Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Bayla Ostrach1, Delesha Carpenter, Larry P Cote
1Department of Research, UNC Health Sciences at MAHEC, Asheville, NC; Family Medicine and Medical Anthropology, Boston University School of Medicine, Boston, MA (BO), Division of Pharmaceutical Outcomes and Policy, Asheville Campus; Health Behavior, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC (DC), Cote Law PLLC, Washington, DC (LPC).
Objectives:
To describe a buprenorphine dispensing bottleneck resulting from a pharmacist-perceived Drug Enforcement Administration "cap" on the amount of buprenorphine that can be ordered or stocked.
Methods:
Expert review and preliminary fieldwork.
Results:
We find no such cap exists, though medication distributors struggle to accurately understand and interpret regulatory guidelines, with implications for medication availability.In states where opioid overdose rates remain higher and efforts to increase the number of eligible health care providers prescribing medications to treat opioid use disorder are underway, patients prescribed buprenorphine products report difficult filling prescriptions and pharmacists perceive limits on how much medication they can order and stock.
Conclusions:
We recommend Drug Enforcement Administration policy clarifications or changes to facilitate distributor interpretation; pharmacist workflow; and patient access to medication. We also advise continuing education with pharmacists and buprenorphine prescribers. These steps would facilitate greater access to lifesaving treatment for opioid use disorder.
Related Concept Videos
Desensitization and Tachyphylaxis
Drug Dependence
Drug Abuse and Addiction: Pharmacological Phenomena
Depolarizing Blockers: Pharmocokinetics
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Drug Elimination: Non-Renal Routes

