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Chitosan-Based Thermo-Sensitive Hydrogel Loading Oyster Peptides for Hemostasis Application.

Dongying Zhang1,2, Zhang Hu1, Lingyu Zhang1

  • 1Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.

Materials (Basel, Switzerland)
|November 13, 2020
PubMed
Summary

A new chitosan-based hydrogel loaded with oyster peptides demonstrates superior hemostatic properties. This advanced wound dressing effectively reduces blood loss and coagulation time, showing promise for trauma emergencies.

Keywords:
chitosanhemostasishydrogeloyster peptides

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Area of Science:

  • Biomaterials Science
  • Hemostasis Research
  • Trauma Care Innovations

Background:

  • Massive hemorrhage is a leading cause of death in trauma.
  • Effective hemostatic agents are crucial for emergency medical interventions.
  • Chitosan-based materials offer potential for wound healing and hemostasis.

Purpose of the Study:

  • To develop and evaluate a novel chitosan-based thermo-sensitive hydrogel loaded with oyster peptides (CS-C/OP/β-GP) for hemostasis.
  • To compare the hemostatic performance and biocompatibility of CS-C/OP/β-GP hydrogel against a commercial gelatin sponge.
  • To assess the potential of CS-C/OP/β-GP hydrogel as a medical dressing for uncontrolled bleeding.

Main Methods:

  • Preparation of CS-C/OP/β-GP hydrogel using catechol-modified chitosan and β-glycerol phosphate at physiological temperature.
  • In vitro evaluation of hemostatic performance, including coagulation time and blood coagulation index.
  • In vitro assessment of platelet adhesion and erythrocyte adsorption.
  • In vivo testing on mouse models for liver injury and tail amputation to measure hemostasis time and blood loss.
  • In vitro cytotoxicity testing on L929 cells and hemolysis assays to evaluate biocompatibility.

Main Results:

  • CS-C/OP/β-GP hydrogel exhibited improved in vitro coagulation and blood coagulation index compared to gelatin sponge.
  • Platelet adhesion and erythrocyte adsorption rates were significantly higher for CS-C/OP/β-GP hydrogel (38.98% and 95.87% increase, respectively).
  • In vivo studies showed a 19.5% reduction in hemostasis time for liver injury and an 18.9% decrease in blood loss in the tail amputation model.
  • Safety evaluations indicated no cytotoxicity to L929 cells and hemolysis rates below 5% at 1 mg/mL, demonstrating good biocompatibility.

Conclusions:

  • CS-C/OP/β-GP hydrogel demonstrates enhanced hemostatic efficacy and superior biocompatibility.
  • The developed hydrogel significantly outperforms commercial gelatin sponge in key hemostatic parameters.
  • CS-C/OP/β-GP hydrogel is a promising candidate for advanced medical hemostatic dressings in trauma care.