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Novel therapeutic approaches for COVID-19 in chronic kidney disease and transplant

Antoney J Ferrey1,2, Ramy Hanna1,2, Uttam G Reddy1,2

  • 1Department of Medicine, Division of Nephrology, Hypertension, and Kidney Transplantation, University of California Irvine Medical Center.

Current Opinion in Nephrology and Hypertension
|November 13, 2020
PubMed
Abstract

Insights

Patients with kidney disease face unique challenges during the SARS-CoV-2 pandemic. This review covers prevention strategies and emerging treatments for COVID-19 in kidney disease patients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Virology

Background:

  • Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) causes a global pandemic.
  • Patients with kidney disease are highly vulnerable due to frequent healthcare system contact for renal replacement therapy.
  • Management of COVID-19 in kidney disease patients requires special consideration due to underlying health complexities.

Purpose of the Study:

  • To review prevention strategies for SARS-CoV-2 in patients with kidney disease.
  • To discuss emerging treatment options for COVID-19 relevant to kidney disease populations.
  • To highlight the unique challenges faced by kidney disease patients during the pandemic.

Main Methods:

  • Literature review of scientific and healthcare publications.
  • Analysis of current treatment modalities and public health interventions.
  • Synthesis of information pertaining to kidney disease patient management.

Main Results:

  • Targeted viral therapies, extracorporeal therapies, and immunosuppressive treatments are key but need careful application in kidney disease patients.
  • Public health interventions are crucial for preventing SARS-CoV-2 spread in this vulnerable group.
  • Emerging treatment options require specific adaptation for patients undergoing dialysis or transplantation.

Conclusions:

  • Effective management of COVID-19 in kidney disease patients necessitates a multidisciplinary approach.
  • Continued research into tailored therapies and preventative measures is essential.
  • Protecting kidney disease patients requires a deep understanding of their unique physiological and treatment-related vulnerabilities.

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