Developments in biosensors for CoV detection and future trends

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Infectious Disease Diagnostics

Background:

• Coronavirus (CoV) poses a significant global health threat, necessitating rapid and accurate diagnostic tools.
• Traditional methods for CoV detection often lack the speed and accessibility required for widespread screening and point-of-care applications.

Purpose of the Study:

• To provide a comprehensive overview of the current state of biosensor technology for Coronavirus detection.
• To analyze the challenges and future perspectives in the development of advanced biosensing platforms for CoV diagnostics.

Main Methods:

• Review of existing literature on affinity-based biosensors (ABBs) for Coronavirus detection.
• Categorization of biosensors based on transduction mechanisms: electrochemical, optical, and piezoelectric.
• Analysis of biorecognition elements, including antibodies and DNA, and their binding interactions.

Main Results:

• Three main categories of affinity-based biosensors (electrochemical, optical, piezoelectric) have been developed for CoV detection.
• Biosensors utilize antibodies and DNA as biorecognition elements, forming antigen-antibody or DNA-target complexes.
• Comparison of analytical performances, advantages, and drawbacks of different biosensor types against traditional methods.

Conclusions:

• Biosensor technology offers promising alternatives to traditional Coronavirus detection methods.
• Further development of biosensing platforms is crucial for effective point-of-care diagnostics and pandemic management.
• This review serves as a reference for future research in biosensor design for infectious disease surveillance.