Application of adrenal maximum standardized uptake value to ¹³¹I-6β-iodomethyl-19-norcholesterol SPECT/CT for...

To evaluate the maximum standardized uptake value (SUVmax) by ¹³¹I-6β-iodomethyl-19-norcholesterol (NP-59) single-photon emission computed tomography (SPECT)/computed tomography (CT) for characterizing unilateral hyperfunctioning adrenocortical masses.

Ten patients underwent NP-59 SPECT/CT to evaluate the following unilateral adrenocortical hyperfuncting masses: three with Cushing's syndrome (CS), three with subclinical CS, and four with primary aldosteronism (PA). Visual and quantitative or semiquantitative analyses (noncontrast CT HU [Hounsfield units], lesion SUVmax, contralateral SUVmax, and SUVmax ratio [lesion SUVmax/contralateral adrenal SUVmax]) were performed. The Mann-Whitney U test or Chi-squared test was used appropriately to assess differences between quantitative variables or compare categorical data. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis.

All adrenal tumors were diagnosed as cortical adenomas. On visual analysis, unilateral uptake was noted in three patients with CS and one patient with subclinical CS, whereas bilateral uptake was noted in four patients with PA and two patients with subclinical CS (p = 0.046). No significant difference was observed in CT HU (p = 0.055). The lesion SUVmax and SUVmax ratio were significantly higher and the contralateral SUVmax was significantly lower in six patients with CS than in four patients with PA (each, p < 0.05). The area under the ROC curve and accuracy for differentiating between CS and PA were, respectively, 0.92 and 90.0 % for the lesion SUVmax, 1.00 and 100 % for the contralateral SUVmax, and 0.92 and 90.0 % for the SUVmax ratio.

Quantitative or semiquantitative analysis using the adrenal SUVmax in adrenocortical NP-59 SPECT/CT has potential for characterizing unilateral hyperfunctioning adrenocortical masses.