Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.8K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Infection01:20

Infection

10.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
10.6K
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

282
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
282

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A yeast-based platform for etoposide production via yatein bioconversion.

Metabolic engineering communications·2026
Same author

Deciphering the role of the Sch9 serine/threonine kinase in <i>Scedosporium apiospermum</i>.

Frontiers in fungal biology·2026
Same author

Cinchona alkaloid scaffold decoded.

Plant communications·2026
Same author

Innovation in antifungal therapy.

EMBO molecular medicine·2026
Same author

TRXR2, a thioredoxin reductase-encoding gene, contributes to protection against the oxidative stress and virulence in Scedosporium apiospermum.

Microbial pathogenesis·2026
Same author

Editorial: Evolutionary adaptation in human-infecting fungi: ecological traits and pathogenicity.

Frontiers in cellular and infection microbiology·2026
Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026
Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026
Same journal

Cronobacter spp.

Trends in microbiology·2026
Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026
Same journal

Critical role of the inflammatory rheostat in influenza-associated pulmonary aspergillosis.

Trends in microbiology·2026
Same journal

Structure-based prokaryotic transcription shapes adaptation and host-invader interplay.

Trends in microbiology·2026
See all related articles

Related Experiment Video

Updated: Nov 30, 2025

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

9.2K

Candida auris Mannans and Pathogen-Host Interplay.

Vishnu Chaturvedi1, Robert J Linhardt2, Nicolas Papon3

  • 1Mycology Laboratory, New York State Department of Health Wadsworth Center, Albany, New York, NY, USA.

Trends in Microbiology
|November 16, 2020
PubMed
Summary
This summary is machine-generated.

A new study reveals how the body fights the dangerous, drug-resistant fungus Candida auris. Researchers identified key fungal components, mannans and mannoproteins, involved in the immune response to this pathogen.

Keywords:
Candida speciescell wallhost defensemannans

More Related Videos

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
03:24

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

1.9K
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

10.2K

Related Experiment Videos

Last Updated: Nov 30, 2025

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

9.2K
Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
03:24

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

1.9K
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

10.2K

Area of Science:

  • Mycology
  • Immunology
  • Infectious Diseases

Background:

  • Candida auris is a multidrug-resistant fungus causing global outbreaks in healthcare settings.
  • This pathogen leads to significant mortality in vulnerable patient populations.
  • Understanding host immune responses is crucial for combating C. auris infections.

Purpose of the Study:

  • To delineate the innate host immune responses against Candida auris.
  • To identify specific fungal components that modulate these immune responses.
  • To provide insights into host-pathogen interactions during C. auris infection.

Main Methods:

  • The study involved analyzing immune cell interactions with C. auris.
  • Investigated the role of fungal cell wall components, specifically mannans and mannoproteins.
  • Utilized in vitro models to assess immune activation and fungal recognition.

Main Results:

  • Innate immune cells mount responses against C. auris.
  • Fungal mannans and mannoproteins play critical roles in modulating host immune cell activity.
  • These components influence the recognition and clearance of the fungus by the immune system.

Conclusions:

  • The study elucidates key mechanisms of innate immunity against Candida auris.
  • Mannans and mannoproteins are identified as critical targets or modulators in host defense.
  • Findings contribute to developing novel therapeutic strategies against C. auris infections.