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Updated: Nov 30, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
A click-ready pH-triggered phosphoramidate-based linker for controlled release of monomethyl auristatin E
Feyisola P Olatunji1, Jacob W Herman1, Brittany N Kesic1
1Washington State University, Department of Chemistry, PO Box 644630, Pullman, WA 99164-4630, United States.
Abstract:
In this work, we developed a novel "click"-ready pH-cleavable phosphoramidate linker for controlled-release of monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at physiological pHs while rapidly releasing its payload at acidic pH. The linker can also be tailored to release payloads of diverse functional groups, broadening its applications.

