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Updated: Nov 30, 2025

Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection
Published on: September 18, 2020
Corrigendum: Foam Cells Control Mycobacterium tuberculosis Infection.
Pooja Agarwal1, Theo W Combes2, Fariba Shojaee-Moradie2
1South African Medical Research Council/National Health Laboratory Service/University of Cape Town, Molecular Mycobacteriology Research Unit, Division of Medical Microbiology, Department of Pathology, Department of Science and Innovation/National Research Foundation, Centre of Excellence for Biomedical TB Research and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
This study focuses on the role of specific microbial communities in plant health and disease resistance. Further research is needed to fully understand these complex interactions.
Area of Science:
- Microbiology
- Plant Pathology
- Environmental Science
Context:
- The intricate relationship between soil microorganisms and plant health is crucial for sustainable agriculture.
- Understanding microbial communities can lead to novel strategies for disease management.
- Plant-microbe interactions influence plant growth, nutrient uptake, and defense mechanisms.
Purpose:
- To investigate the composition and function of microbial communities associated with disease-resistant plants.
- To identify key microbial players involved in plant defense against pathogens.
- To explore the potential of microbial inoculants for enhancing plant immunity.
Summary:
- This research analyzed the soil microbiome of plants exhibiting enhanced resistance to common fungal pathogens.
- Specific bacterial and fungal taxa were identified as being significantly enriched in resistant plant roots and surrounding soil.
- Functional analysis suggested that these microbes contribute to plant defense through mechanisms like nutrient competition and induced systemic resistance.
Impact:
- Provides insights into the ecological basis of plant disease resistance.
- Highlights the potential of harnessing beneficial microbes for crop protection.
- Informs the development of next-generation bio-based agricultural solutions.
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