Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebellar astrocytomas. Part II. Pathologic features indicative of malignancy.

E B Ilgren1, C A Stiller

  • 1Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.

Clinical Neuropathology
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conditional survival of children, adolescents and young adults (0-24 years) diagnosed with leukaemia during 2000-2014 world-wide: (CONCORD-3).

European journal of cancer (Oxford, England : 1990)·2025
Same author

Socio-economic and ethnic disparities in childhood cancer survival, Yorkshire, UK.

British journal of cancer·2023
Same author

Childhood cancer research in Oxford I: the Oxford Survey of Childhood Cancers.

British journal of cancer·2018
Same author

Cancer risk in children born after donor ART.

Human reproduction (Oxford, England)·2017
Same author

Trends in survival for teenagers and young adults with cancer in the UK 1992-2006.

European journal of cancer (Oxford, England : 1990)·2015
Same author

Descriptive epidemiology of Kaposi sarcoma in Europe. Report from the RARECARE project.

Cancer epidemiology·2014

Pathologic features like pleomorphism, mitotic figures, and necrosis in cerebellar astrocytomas indicate poor prognosis. Identifying these malignant signs is crucial for predicting patient survival and recurrence risk.

Area of Science:

  • Neuropathology
  • Oncology
  • Pediatric Oncology

Background:

  • Cerebellar astrocytomas are primary brain tumors with variable clinical outcomes.
  • Understanding specific histopathologic features is key to predicting prognosis.

Purpose of the Study:

  • To identify and describe pathologic features associated with poor clinical outcomes in cerebellar astrocytomas.
  • To correlate these features with survival time and recurrence rates.

Main Methods:

  • Retrospective review of 112 cerebellar astrocytoma cases (1938-1984).
  • Analysis of histopathologic features including pleomorphism, mitotic figures, cellularity, desmoplasia, perivascular pseudorosettes, and necrosis.
  • Comparison with existing literature.

Related Experiment Videos

Main Results:

  • Marked pleomorphism, presence of mitotic figures, marked cellularity, marked desmoplasia, isolated perivascular pseudorosettes, and marked necrosis are associated with significantly reduced survival.
  • Certain features like pleomorphism and mitotic figures are more common in adults and solid tumors.
  • Perivascular pseudorosettes indicate favorable outcomes when associated with microcystic change and endothelial hyperplasia, but poor outcomes in isolation.

Conclusions:

  • Specific histopathologic findings can predict poor outcomes in cerebellar astrocytomas.
  • These features, including pleomorphism and mitotic activity, are critical for classifying malignant potential.
  • Early identification of these markers aids in prognostic assessment and patient management.