Classification of cephalosporins
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Updated: Aug 9, 2026

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
Published on: August 16, 2017
1Department of Medical Microbiology, London Hospital Medical College, University of London.
Abstract:
Many cephalosporins are now in clinical use. They have a wide range of activity against different species of bacteria and also differ in their pharmacokinetic and metabolic characteristics. This article outlines a basis for comparison and classification of cephalosporins into 4 groups active mainly against: (1) Gram-positive bacteria; (2) Gram-negative rods; (3) Gram-negative rods including Pseudomonas spp.; and (4) Gram-negative rods including Bacteroides spp. Further subdivisions highlight the pharmacological differences.
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